The truth is, if you want to bring real issues/solutions on the table, if you want to be involved in the tensions of the society, if you want to highlight some differences and see how your product can play a role there…there is only one way, PLAY IT HONEST.
The brain is one of the most vital organs in the human body, so damage to the brain from injury or aging can have major impacts on people’s quality of life. Neurological disorders represent some of today’s most devastating medical conditions that are also difficult to treat. Usually, research involving Alzheimer’s rely on brain cells from mice. Now, neurobiologists from the University of California, Irvine (UCI) have developed a method that could allow the use of human cells instead of animal ones to help understand neurological diseases better.
In their study, which was published in the journal Neuron, the researchers found a way to transform human skin cells into stem cells and program them into microglial cells. The latter make up about 10 to 15 percent of the brain and are involved in the removing dead cells and debris, as well as managing inflammation. Micgrolia are instramental in neural network development and maintenance, explained researcher Mathew Blurton Jones, from UCI’s Department of Neurobiology & Behavior.
The skin cells had been donated by patients from UCI’s Alzheimer’s Disease Research Center. These were first subjected to a genetic process to convert them into induced pluripotent stem (iPS) cells — adult cells modified to behave as an embryonic stem cell, allowing them to become other kinds of cells. These iPS cells were then exposed to differentiation factors designed to imitate the environment of developing microglia, which transformed them into the brain cells.
“This discovery provides a powerful new approach to better model human disease and develop new therapies,” said UCI MIND associate researcher Wayne Poon. The researchers, in effect, have developed “a renewable and high-throughput method for understanding the role of inflammation in Alzheimer’s disease using human cells,” according to researcher Edsel Abud in the same source.
In other words, by using human microglia instead of those from mice, the researchers have developed a more accurate tool to study neurological diseases and to develop more targeted treatment approaches. In the case of Alzheimer’s, they studied the genetic and physical interactions between the disease’s pathology and the induced microglia cells. “These translational studies will better inform disease-modulating therapeutic strategies,” Abud added in the press release.
Furthermore, they are now using these induced microglia cells in three-dimensional brain models. The goal is to understand the interaction between microglia and other brain cells, and how these influence the development of Alzheimer’s and other neurological diseases.
This is all made possible by reprogrammable stem cells. Indeed, this study is one more example of how stem cells are changing medicine. I can’t wait to see more of that, amazing things happen for the human being…and certainly to our relation to the world.
A new post after a long time – my involvement in the French presidential elections keeps getting a lot of my time. Am I happy as a Dane? It looks like it so far. Maybe it calls for a Carlsberg.
We all make bad decisions sometimes, but have you ever wondered what mental obstacles can lead you to do so? Check this infographic on 20 of the most common cognitive biases that can mess with your head when it’s decision time. This graphic is from Samantha Lee and Shana Lebowitz and surely, you will recognise some real-life situation.
Just for the pleasure…the rest of the conversation is available everywhere in all your favorites websites, blogs and social media. Maybe a good intention but, overall, a failure. We can still share why over here…
And another point of view…from 1971
Step aside Nike, Apple and Vice, there’s a new ‘cool and hip’ brand in town – and it’s Google. The Big G funded a research to find out which brands are most popular among Generation Z and it turns out today’s teenagers think nothing is cooler than Google – not even Xbox, Playstation or Snapchat ranked as more “unique, impressive, interesting, amazing, or awesome” than Google and its products. While Gen Z usually refers to those born between the mid-1990s to early 2000s, the Mountain View behemoth focused on American teenagers aged 13 to 17 to reach this conclusion. The findings were published in an equally cool-titled ‘magazine’ called It’s Lit: A guide to what teens think is cool.
As the team behind the holy GBook of Cool explains, the survey was compiled to offer insight into what brands teenagers religiously pay attention to and get most excited about. The data provided reflects a sample of 1,100 teens and 122 brands. “Unlike millennials,” the study found Gen Z’ers are “ambitious, engaged, and feel like they can change the world” which is why it was so important to pinpoint what the young leaders of tomorrow find cool – that and the $44 billion purchasing power they hold. YouTube – which is owned by Google – and Netflix topped the charts as the two coolest and most recognized services among Gen Z, followed by Google in the number three spot.
While brands like Facebook, Yahoo and AT&T were pretty well-known, teens didn’t deem them particularly cool. In fact, Yahoo was among the four ‘least cool’ brands, accompanied by Sprint, TMZ and The Wall Street Journal. Vice wasn’t that cool either, coming in near the tail end along with The Wall Street Journal. Least known among Gen Z were clothing brands Uniqlo, Patagonia and Supreme, as well as home automation giant Nest.
The research further indicated that while millennials tend to have a preference for Playstation, teenagers would much rather game on Xbox. Interestingly, the study found that Gen Z’ers used Google+ more often than Twitter and Instagram – though that’s hardly surprising given Google’s undeniable coolness. While Google is usually trustworthy, this one made me raise an eyebrow. Find out what Gen Z thinks is cool these days and browse through the It’s Lit report here.
(source – The Next Web)
The storytelling pattern was overused…but let’s be honest. We keep emotional the same each time.